There was a time women reporting extreme fatigue and pain in the upper back were diagnosed with anxiety or the effects of menopause and sent home to relax. That’s quickly changing with the growing recognition that heart disease can look different in women. It is often more complicated to diagnose, too, which is one reason there’s a higher proportion of unrecognized or “silent” heart attacks among women than men.

Knowing the steps leading to diagnosis can help result in a quick and accurate finding and the best treatment for you.


Doctors may use well-established formulas, such as the Framingham Risk Score, when assessing a patient for heart disease. Such scores estimate the probability that a person will develop cardiovascular disease within the next 10 years. Your risk level is based on your age, sex, smoking status, blood pressure measurement, diabetes status, family risk and cholesterol levels. Healthcare professionals should take several additional factors into consideration, including medical and lifestyle history, family history of heart disease, possible early signs of heart disease and other conditions.

No matter what type of heart disease you have, your doctor will likely perform a physical exam and ask about your personal and family medical history before doing any tests. The tests needed to diagnose your heart disease will depend on what condition your doctor thinks you might have. The medical team also will give you a physical exam to check your blood pressure, weight, body composition and other factors. If heart disease is suspected, your family physician will refer you to a cardiologist or order diagnostic tests.

The traditional approach in diagnosis is to look for blockages in blood flow, but women with heart disease are less likely to have obstructions and more likely to have poorly functioning blood vessels. That means the arteries and capillaries aren’t working as they should, which reduces the amount of blood flowing to the heart muscle. Focusing too narrowly on finding obstructions can lead to misdiagnosis in some women, so medical guidelines have been rewritten to advise doctors to broaden their investigations.

Diagnostic Tests

There are many possible tests to help make a diagnosis of heart disease, ranging from a treadmill exercise test to sophisticated nuclear imaging. Your doctor or a cardiologist will decide which of the available tests are most appropriate for you while taking into consideration that some tests are less accurate in women. Some common tests include those listed below:

Electrocardiogram (ECG)An electrocardiogram is the most common test for heart rhythm conditions. It can also be used to diagnose a heart attack in a person with suggestive symptoms. An electrocardiogram machine records your heart's rhythm onto paper through sticky electrodes which are placed on your chest, arms and legs. The recording will show if the heart muscle is damaged or short of oxygen is the setting of a heart attack, and detect any irregularities of the heart rhythm.

Holter MonitorThe Holter monitor is a portable device used to make a continuous recording of your heart rate and rhythm as you go about your daily routine. Information from the device is used to detect any heart rhythm abnormalities, to help determine whether your medications need adjusting, or to match your symptoms with the heart’s electrical activity. If you have signs and symptoms of an arrhythmia such as palpitations (episodes of rapid or irregular heartbeats) or unexplained fainting or dizziness, your doctor may recommend wearing a Holter monitor for 48 hours. Over that period of time, abnormalities in your heart rate and rhythm can be recorded. Additionally, you can press the Event Button whenever you feel a specific symptom which helps to document how your symptoms might be related to any abnormal electrical activity in your heart.

Blood Tests: Blood tests can help to diagnose a heart condition or to monitor someone who has already been diagnosed with a heart condition. Blood tests can also be taken to monitor the effects of medication as well as the levels of minerals in the blood, and to quantify cardiovascular risk factors such as cholesterol and blood sugar. There is a highly sensitive blood test that measures your levels of a protein known as troponin. Troponin is released when your heart faces significant stress or gets damaged. This test is commonly used to diagnose a heart attack, but Troponin can also be elevated in other conditions.

Echocardiogram (ECHO)This test uses sound waves to study the structure and function of your heart, and how the heart and valves are working. A probe sends out and records these sound waves, producing a moving image of your heart on a screen. Echocardiogram is typically done to evaluate the heart’s function, the valves, the aorta, the sac that surrounds the heart (pericardium), or as part of a stress test.

Coronary Computed Tomography Angiogram (Coronary CTA)This is a type of computed tomography (CT) scan that can help diagnose coronary artery disease. It gives a 3-dimensional image of the heart chambers and coronary arteries supplying blood to the heart. Coronary CTA is most useful in younger individuals (younger than ~65 years of age) and in those without previous coronary artery stents.

Magnetic Resonance Imaging (MRI)An MRI uses magnets to create detailed images of your heart on a computer. It can take still or moving pictures of your heart. It does not involve radiation.  Sometimes a special dye is used to make parts of the heart and blood vessels easier to see. This test shows your doctor the structure of your heart and how well it is working, so they can decide the best treatment for you. It is also used to evaluate the aorta, the body’s biggest blood vessel.

Coronary Angiography or Coronary Catheterization (CATH)Coronary angiography involves a small tube being inserted into an artery in the arm or leg and threaded through the aorta to reach the coronary arteries in your heart. A special dye is injected through the catheter into your bloodstream. Using the dye as a highlight, X-ray pictures of the heart and coronary arteries are taken. This is the gold-standard test to evaluate for coronary artery blockage; but because it is invasive, it is reserved for special situations such as heart attacks, unstable angina, pre-heart surgery, or any other situation when your doctor has a strong suspicion for coronary artery blockages as a cause for symptoms.

Stress Tests: Stress tests help your doctor find out how well your heart works when you're physically active, using either exercise machines (e.g. a treadmill or bike) or a medication to “stress” the heart (such as dobutamine, dypiridamole, adenosine or regadenoson).

  • Exercise Stress Test: This is an electrocardiogram (ECG) done while you exercise or a bike or treadmill. The technician checks your heart rate, heart rhythm, ECG tracings and blood pressure. This test can help your doctor determine whether the heart is a cause for your symptoms.
  • Nuclear Cardiac Stress Test/ Myocardial Perfusion Scan/ Persantine Myoview/ Single Photon Emission Computed Tomography (SPECT): All of the above names can be used to describe the same test. This is a type of stress test that can be done with either exercise or a medication to stress the heart. A tiny dose of a radioactive substance called a 'tracer' is injected into your bloodstream before and after the “stress” part of the test. The tracer goes to your heart and releases energy. Special cameras take a picture of this energy from outside your body, at rest and after the stress. Your doctor uses this picture to see how much blood flows to your heart muscle during resting and stress conditions. This information helps your doctor determine if your heart muscle is damaged.
  • Stress Echocardiogram (STRESS ECHO): A stress echocardiogram (stress echo) is an imaging test that uses ultrasound to show how well your heart works during stress (induced by exercise or medication). Based on how the different parts of your heart move during stress conditions, the doctor can determine whether your heart may be suffering from poor blood flow (due to blockages of the coronary arteries). This test can also be used for other indications, such as determining severity of valve disease.

Cardiac Positron emission tomography (PET): Cardiac PET can be used for 3 main reasons: (1) as another type of nuclear stress test (as described above), (2) as viability imaging to assess how much heart muscle has been damaged by a heart attack, and how much heart muscle is still “alive” and would benefit from improvements in blood flow, and (3) to detect inflammation in the heart, such as in cardiac sarcoidosis or myocarditis, for example. A different type of nuclear tracer is used for the different indications.